Maulia, P. H., & Farapti. (2019). Status Zinc dan Peran Suplementasi Zinc terhadap Sistem Imun pada Pasien HIV/AIDS: A Systematic Review. Media Gizi Indonesia, 14(2), 115-122. https://doi.org/10.204736/mgi.v14i2.115–122
This research focused on analyzing zinc status in HIV/AIDS patients and examine the effect of zinc supplementation which was related to immunity status. Other studies had stated that micro-nutrients such as zinc may play crucial role in immunity cells activity, in which low level of zinc in PLHIV can further impact their disease progression and mortality rate. A systematic review was done using a comprehensive search method and critical appraisal process, which resulted in 9 articles about HIV infected adults who underwent outpatient care receiving zinc supplementation. Said articles depict that most HIV/AIDS patients have low plasma zinc level and there was an increase in CD4+ level after continuous zinc supplementation. Positive improvements from other infections such as diarrhea and tuberculosis also occur from the supplementation. Therefore, the researchers conclude that zinc level benefits HIV patients by improving their immune system. Although this study was done in a form of review, such information can be considerably useful in developing more effective HIV treatments, particularly with the use of micro-nutrients.