Genotypic Characterization of Human Immunodeficiency Virus Type 1 Prevalent in Kepulauan Riau, Indonesia


BIBLIOGRAPHY

Khairunisa, S. Q., Ueda, S., Witaningrum, A. M., Matondang, M. Q., Y., Indriati, D. W., Kotaki, T., … Kameoka. (2018). Genotypic Characterization of Human Immunodeficiency Virus Type 1 Prevalent in Kepulauan Riau, Indonesia. AIDS Research and Human Retroviruses, 34(6), 555–560. doi:10.1089/aid.2018.0040

ANNOTATED BIBLIOGRAPHY

This research was particularly aimed to identify HIV-1 subtypes and circulating recombinant forms (CRFs) present in Kepulauan Riau, Indonesia, along with monitoring HIV drug resistance (HIVDR) among individuals undergoing ARV. As HIV-1 infection was increasing in Kepulauan Riau, total of 62 individuals with matching criterion were selected and their blood samples were taken for viral genomic analyses. Result of subtyping showed that CRF01_AE was the most prevalent HIV subtype among the samples and there seem to be low major mutations in the viral gene encoding reverse transcriptase. This means that HIVDR prevalence in the selected region was found to be low. Further and larger surveillance study regarding drug resistance associated mutations of HIV was stated to be necessary by the researchers in order to monitor the emergence of HIVDR. Such research is considerably important for the development of HIV treatments due to drug resistance being analyzed in the study, along with the most occurring type of virus in Indonesia’s region.